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In a recent research, we reported the identification as well as characterization of a whole new atypical opioid receptor with distinctive destructive regulatory Homes in direction of opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a broad-spectrum